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Rabbit Anti-Doppel/PE-Cy7 Conjugated antibody (bs-11732R-PE-Cy7)
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说 明 书:100ul  
100ul/2980.00元
大包装/询价
产品编号bs-11732R-PE-Cy7
英文名称Anti-Doppel/PE-Cy7
中文名称PE-Cy7标记的朊蛋白DPL抗体
别    名DPL; Dublet; MGC41841; Prion gene complex downstream; Prion like protein doppel; Prion protein 2 (dublet); Prion protein 2; Prion-like protein doppel; PRND; PRND_HUMAN; PrPLP.  
规格价格100ul/2980元购买        大包装/询价
说 明 书100ul  
研究领域细胞生物  神经生物学  细菌及病毒  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, 
产品应用ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量14kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Doppe1 (51-120aa)
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25% sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.

Subcellular Location:
ell membrane; Lipid-anchor, GPI-anchor

Tissue Specificity:
Expressed in testis.

Similarity:
Belongs to the prion family.

Database links:

Entrez Gene: 23627 Human

Entrez Gene: 26434 Mouse

Entrez Gene: 113910 Rat

Omim: 604263 Human

SwissProt: Q9UKY0 Human

SwissProt: Q9QUG3 Mouse

Unigene: 406696 Human

Unigene: 180750 Mouse

Unigene: 94278 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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